Revo Uninstaller is one great application.  Now some of you may be thinking, "Why would I need this, all programs have uninstallers and if they don't Windows has it's Add/Remove feature..."  While that is true, both ANY program's and Windows' Add/Remove app are not ideal.  Here's why, when you uninstall a program MOST programs leave their 'program files' folder and sometimes some stuff in it + application data is left on your PC (if you ever decide to reinstall the app) + Registry info ...
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Piriform's CCleaner is the best thing you can add to your computer.  This program will clean temp files, internet cache/cookies/history, recycle bin, and more.  It also has a minimal Registry Cleaner, which is great because some registry cleaners do too much and delete needed entries.  This is also a free app.  It can easily be set to run during start-up or shutdown.

CCleaner site

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Auslogics Disk Defrag is the quickest and most efficient Disk Defragmenting program I have ever used.  You can schedule it to run when you want so you no longer need to worry about dealing with Defrags.  Also, you can change the priority, which means it can be set to use more or less CPU, which is great if it runs in the background while your doing other tasks.  The greatest thing is this program is totally FREE.

Auslogic's site

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